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Endocrine-disrupting chemicals (EDCs) substantially cost society as a result of increases in disease and disability but—unlike other toxicant classes such as carcinogens—have yet to be codified into regulations as a hazard category.This Series paper examines economic, regulatory, and policy approaches to limit human EDC exposures and describes potential improvements. In the EU, general principles for EDCs call for minimisation of human exposure, identification as substances of very high concern, and ban on use in pesticides. In the USA, screening and

AbstractThe world faces an increasing need to phase out harmful chemicals and design sustainable alternatives across various consumer products and industrial applications. Alternatives assessment is an emerging field focusing on identifying viable solutions to substitute harmful chemicals. However, current methods fail to consider trade-offs from human and ecosystem exposures, and from impacts associated with chemical supply chains and product life cycles. To close this gap, we propose a life cycle based alternatives assessment (LCAA) framework for consistently integrating quantitative exposure

Microplastic contamination of the marine environment is widespread, but the extent to which the marine food web is contaminated is not yet known. The aims of this study were to go beyond visual identification techniques and develop and apply a simple seafood sample cleanup, extraction, and quantitative analysis method using pyrolysis gas chromatography mass spectrometry to improve the detection of plastic contamination.This method allows the identification and quantification of polystyrene, polyethylene, polyvinyl chloride, polypropylene, and poly (methyl methacrylate) in the