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Environmental research is detecting ever more pharmaceutical residues in the aquatic environment as analytical methods become increasingly sensitive. The physicochemical properties of some active substances suggest an accumulation in sediment, suspended matter and biota. Hence, these matrices could be interesting alternative matrices for monitoring of pharmaceutical residues in surface waters. Against this background, modern analytical detection methods for different matrices from water to sediment and suspended matter to biota (fish) were developed and published in 2019 (FKZ 3715 67 413). In the current project sampling concepts were combined with retrospective analyses. In this report, the results of the developed methods from investigations of water, sediment, suspended matter and biota samples from different locations and the German environmental specimen bank are presented in terms of occurrence and distribution.

Persistence is a hazard criterion for chemicals enshrined in chemical regulation worldwide. In this paper, we argue that the higher the persistence of a chemical, the greater the emphasis that it should be given in chemicals assessment and decision making. We provide case studies for three classes of highly persistent chemicals (chlorofluorocarbons, polychlorinated biphenyls, and per- and polyfluoroalkyl substances) to exemplify problems unique to highly persistent chemicals, despite their otherwise diverse properties.

Characterizing the degradation behavior of chemicals in the environment is a key component of chemical hazard and risk assessment. Persistence has been successfully characterized for readily and for slowly degradable chemicals using standardized tests, but for the third group of chemicals with intermediate degradability (“middle group”), the assessment is less straightforward. Whether chemicals of this group behave as persistent or not in a given environment depends on environmental factors such as the presence of sorbents that can limit the bioavailability of chemicals. 

For a large part of the active pharmaceutical ingredients (APIs) available on the market, there is no or no comprehensive environmental risk assessment (ERA) existent/available. Existing ERAs are, moreover, treated as commercially/industrial confidential information (CCI) and the information content on the ERAs contained in the Public Assessment Reports is very limited. Thus, neither the public can inform itself sufficient nor environmental authorities can use the ERAs to compile environmental quality standards. Environmental information law, on the other hand, requires the general accessibility of environmental information. Against this background, this investigation examines the following questions in conformity with the environmental information law: Which environmental information on pharmaceuticals is generated in the marketing authorisation? 

Per- and polyfluoroalkyl substances (PFAS) are a large class of thousands of synthetic chemicals that are used throughout society. However, they are increasingly detected as environmental pollutants and some are linked to negative effects on human health.

This page from the European Chemicals Agency provides background on PFAS chemicals and their use in a number of products, including construction materials, paints and chrome plating.

On 13th January 2023, the European Commission issued a proposal that would ban the manufacture and use of PFAS chemicals, including those used in building materials. 

The details of the proposed restriction of around 10,000 per- and polyfluoroalkyl substances (PFASs) are now available on ECHA’s website. ECHA’s scientific committees have begun to evaluate the proposal in terms of the risks to people and the environment, and the impacts on society, in accordance with the below timeline.  A six-month consultation began in March 2023 and will close on 25 September 2023.

Document: Consultation on a proposed restriction on the manufacture, placing on the market and use of per- and polyfluoroalkyl substances (PFAS)

This study, commissioned by DG Environment for the European Commission and produced by Wood and Ramboll.  The objective was to assess the use of PFASs and fluorine-free alternatives in textiles, upholstry, carpets, leather and apparel, including specific focus on volumes of use, technical function, and emissions.

Non-fluorine alternatives considered were hydrocarbons, silicones, dendrimers, polyurethane, nanomaterials, and alternative technologies.  The study makes recommendations for policy, including a REACH restriction on the placing on the market and use of these products that contain any PFAS, and a listing under the Stockholm Convention.  It is also recommended in the report that a restriction could be combined with voluntary industry measures and provisions in public procurement to encourage substitution of PFAS before mandatory legislation is introduced.

The Green Science Policy Institute's page on building materials, linking to background information on issues with PFAS, and halogenated flame retardants in insulation.

HBN tested 94 commercially available paint products for the presence of harmful per- and polyfluoroalkyl substances (PFAS), called “forever chemicals”. Approximately 50% of ‌paints tested positive for fluorine, a marker of PFAS. Review the details of our findings and the recommended actions you can take.