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Guidance on key considerations for the identification and selection of safer chemical alternatives

The aim of the guidance is to advance broader agreement on a general approach and criteria for the selection of safer alternatives, with a focus on chemical substitution. It is intended to advance a consistent understanding of the minimum requirements needed to determine whether a chemical alternative is safer than the priority chemical, product, or technology for substitution, independent of the entity performing the assessment or the alternatives assessment framework being used.

The guidance focuses on minimum assessment criteria and recommended assessment practices for four core areas of alternatives assessments:

  1. Determining the assessment’s scope;
  2. Comparative hazard assessment;
  3. Comparative exposure assessment; and
  4. The integration of hazard and exposure results to select a safer alternative.

The guidance also includes recommendations for moving beyond the minimum criteria and assessment practices.