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AbstractThe world faces an increasing need to phase out harmful chemicals and design sustainable alternatives across various consumer products and industrial applications. Alternatives assessment is an emerging field focusing on identifying viable solutions to substitute harmful chemicals. However, current methods fail to consider trade-offs from human and ecosystem exposures, and from impacts associated with chemical supply chains and product life cycles. To close this gap, we propose a life cycle based alternatives assessment (LCAA) framework for consistently integrating quantitative exposure

Endocrine-disrupting chemicals (EDCs) substantially cost society as a result of increases in disease and disability but—unlike other toxicant classes such as carcinogens—have yet to be codified into regulations as a hazard category.This Series paper examines economic, regulatory, and policy approaches to limit human EDC exposures and describes potential improvements. In the EU, general principles for EDCs call for minimisation of human exposure, identification as substances of very high concern, and ban on use in pesticides. In the USA, screening and

Plastics are used across the economy and in diverse downstream sectors such as packaging, construction, transportation, healthcare, textiles, and electronics. Durable products, ranging from construction materials to medical devices make up nearly half of the global plastics market, while packaging products are the largest uses of single-use plastics. Some plastics contain chemicals that are considered to be harmful for health and the environment. Phthalates, poly-fluorinated chemicals, bisphenol A (BPA), brominated flame retardants and antimony trioxide are considered most harmful for

This document has been developed for officials in government who have a role in regulating lead paint, to provide them with concise technical information on the rationale and steps required to phase out lead paint. “Lead paint” or “lead-based paint” is paint to which one or more lead compounds have been intentionally added by the manufacturer to obtain specific characteristics. This document explains the health and economic importance of preventing lead exposure by establishing legally binding controls to stop the

Lead has toxic effects on almost all body systems and is especially harmful for children and pregnant women. Lead paint is an avoidable source of exposure to lead. “Lead paint” or “lead-based paint” is paint to which one or more lead compounds have been intentionally added by the manufacturer to obtain specific characteristics. One important way to prevent exposure is for countries to establish legally binding regulatory measures prohibiting the addition of lead to paint.This policy brief summarizes key information

Medicinal products are physiologically highly active substances that enter the water and soil, particularly through human and animal excretion. They are being detected in the environment to a greater and greater extent, often in concentrations that are not harmless to humans and other living organisms. The consumption of pharmaceuticals is increasing, mainly due to the aging of the population. Consequently, measures to reduce environmental pollution are therefore necessary.

The OECD releases the Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. The document is intended to provide guidance for evaluating chemical using standardised test guidelines. Specific objectives include providing a description of the OECD conceptual framework

This paper examines one specific theme of the democracy-environment interface of environmental governance: the participation of stakeholders in environmental policy formulation and implementation.After a short discussion of environmental governance, its main functions and challenges, the paper addresses the issue of stakeholder participation and the claim of a “democratic deficit” in international environmental governance. It stresses that while stakeholder involvement does not increase the democratic legitimacy, it may nevertheless increase the quality and through this the legitimacy of environmental policy processes

Earth is running out of resources needed for manufacturing materials such as chemicals, minerals, and petroleum. Thus, these components are available only at increasing economic and environmental costs. As an important contribution to a sustainable future, chemistry and its products must be adapted to a circular economy (CE)—a system aimed at eliminating waste, circulating and recycling products, and saving resources and the environment.Nearly 140,000 industrial chemicals are marketed worldwide, and new chemicals are becoming more complex (e.g., stereochemistry, functional groups)

As the basis for managing the risks of chemical exposure, the Chemical Risk Assessment (CRA) process can impact a substantial part of the economy, the health of hundreds of millions of people, and the condition of the environment. However, the number of properly assessed chemicals falls short of societal needs due to a lack of experts for evaluation, interference of third party interests, and the sheer volume of potentially relevant information on the chemicals from disparate sources.In order to explore