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AbstractThe world faces an increasing need to phase out harmful chemicals and design sustainable alternatives across various consumer products and industrial applications. Alternatives assessment is an emerging field focusing on identifying viable solutions to substitute harmful chemicals. However, current methods fail to consider trade-offs from human and ecosystem exposures, and from impacts associated with chemical supply chains and product life cycles. To close this gap, we propose a life cycle based alternatives assessment (LCAA) framework for consistently integrating quantitative exposure

This WHO policy brief presents the consequences of lead exposure on human health and details its toxicity in the body system explaining why it is important to reduce the use and releases of lead, and to reduce environmental and occupational exposures, particularly for children and women of childbearing age.The policy brief also lists the sources of lead releases and contamination in industrial process, drinking water and domestic sources. The brief also gives guidelines for tolerable intake levels of lead and

We present a list of Chemicals of Concern (CoCs) in plastic toys. We started from available studies reporting chemical composition of toys to group plastic materials, as well as to gather mass fractions and function of chemicals in these materials. Chemical emissions from plastic toys and subsequent human exposures were then estimated using a series of models and a coupled near-field and far-field exposure assessment framework. Comparing human doses with reference doses shows high Hazard Quotients of up to 387