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Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. 

Environmental research is detecting ever more pharmaceutical residues in the aquatic environment as analytical methods become increasingly sensitive. The physicochemical properties of some active substances suggest an accumulation in sediment, suspended matter and biota. Hence, these matrices could be interesting alternative matrices for monitoring of pharmaceutical residues in surface waters. Against this background, modern analytical detection methods for different matrices from water to sediment and suspended matter to biota (fish) were developed and published in 2019 (FKZ 3715 67 413). In the current project sampling concepts were combined with retrospective analyses. In this report, the results of the developed methods from investigations of water, sediment, suspended matter and biota samples from different locations and the German environmental specimen bank are presented in terms of occurrence and distribution.

Persistence is a hazard criterion for chemicals enshrined in chemical regulation worldwide. In this paper, we argue that the higher the persistence of a chemical, the greater the emphasis that it should be given in chemicals assessment and decision making. We provide case studies for three classes of highly persistent chemicals (chlorofluorocarbons, polychlorinated biphenyls, and per- and polyfluoroalkyl substances) to exemplify problems unique to highly persistent chemicals, despite their otherwise diverse properties.

For a large part of the active pharmaceutical ingredients (APIs) available on the market, there is no or no comprehensive environmental risk assessment (ERA) existent/available. Existing ERAs are, moreover, treated as commercially/industrial confidential information (CCI) and the information content on the ERAs contained in the Public Assessment Reports is very limited. Thus, neither the public can inform itself sufficient nor environmental authorities can use the ERAs to compile environmental quality standards. Environmental information law, on the other hand, requires the general accessibility of environmental information. Against this background, this investigation examines the following questions in conformity with the environmental information law: Which environmental information on pharmaceuticals is generated in the marketing authorisation? 

This document summarises lessons learned from the various project activities in three sectors: electrical and electronic equipment (EEE); building and construction; and toys. It also formulates key messages addressed to different stakeholder groups and provides links to guidance and tools developed under the GEF project

The video covers the crucial issues surrounding chemical policies in today's world, the unseen effects of chemicals in everyday life and the global push for policies that foster sustainable practices. The video highlights the challenges and innovative solutions that aim to to protect our environment and health, setting the stage for a greener, safer and sustainable future.