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AbstractThe world faces an increasing need to phase out harmful chemicals and design sustainable alternatives across various consumer products and industrial applications. Alternatives assessment is an emerging field focusing on identifying viable solutions to substitute harmful chemicals. However, current methods fail to consider trade-offs from human and ecosystem exposures, and from impacts associated with chemical supply chains and product life cycles. To close this gap, we propose a life cycle based alternatives assessment (LCAA) framework for consistently integrating quantitative exposure

Earth is running out of resources needed for manufacturing materials such as chemicals, minerals, and petroleum. Thus, these components are available only at increasing economic and environmental costs. As an important contribution to a sustainable future, chemistry and its products must be adapted to a circular economy (CE)—a system aimed at eliminating waste, circulating and recycling products, and saving resources and the environment.Nearly 140,000 industrial chemicals are marketed worldwide, and new chemicals are becoming more complex (e.g., stereochemistry, functional groups)

Microplastic contamination of the marine environment is widespread, but the extent to which the marine food web is contaminated is not yet known. The aims of this study were to go beyond visual identification techniques and develop and apply a simple seafood sample cleanup, extraction, and quantitative analysis method using pyrolysis gas chromatography mass spectrometry to improve the detection of plastic contamination.This method allows the identification and quantification of polystyrene, polyethylene, polyvinyl chloride, polypropylene, and poly (methyl methacrylate) in the

We present a list of Chemicals of Concern (CoCs) in plastic toys. We started from available studies reporting chemical composition of toys to group plastic materials, as well as to gather mass fractions and function of chemicals in these materials. Chemical emissions from plastic toys and subsequent human exposures were then estimated using a series of models and a coupled near-field and far-field exposure assessment framework. Comparing human doses with reference doses shows high Hazard Quotients of up to 387

Reducing chemical pressure on human and environmental health is an integral part of the global sustainability agenda. Guidelines for deriving globally applicable, life cycle–based indicators are required to consistently quantify toxicity impacts from chemical emissions as well as from chemicals in consumer products. In response, we elaborate the methodological framework and present recommendations for advancing near-field/far-field exposure and toxicity characterization, and for implementing these recommendations into the scientific consensus model USEtox.The present work was supported by the “Global Best Practices

What is CAt and where does all the data come from?The Chemical Awareness toolkit (CAt) is a free web application that provides rapid access to chemical information for product stewards, risk assessors, toxicologists, chemists, microbiologists, engineers, and other researchers. It includes screening tools that provide chemical information including toxicological hazards, environmental fate, persistence & bioaccumulation, occupational exposure limits, government regulations, and public perception.CAt utilizes an integrated database containing information from key lists provided by Verisk 3E, publicly available lists, databases