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AbstractThe world faces an increasing need to phase out harmful chemicals and design sustainable alternatives across various consumer products and industrial applications. Alternatives assessment is an emerging field focusing on identifying viable solutions to substitute harmful chemicals. However, current methods fail to consider trade-offs from human and ecosystem exposures, and from impacts associated with chemical supply chains and product life cycles. To close this gap, we propose a life cycle based alternatives assessment (LCAA) framework for consistently integrating quantitative exposure

Plastics are used across the economy and in diverse downstream sectors such as packaging, construction, transportation, healthcare, textiles, and electronics. Durable products, ranging from construction materials to medical devices make up nearly half of the global plastics market, while packaging products are the largest uses of single-use plastics. Some plastics contain chemicals that are considered to be harmful for health and the environment. Phthalates, poly-fluorinated chemicals, bisphenol A (BPA), brominated flame retardants and antimony trioxide are considered most harmful for

Earth is running out of resources needed for manufacturing materials such as chemicals, minerals, and petroleum. Thus, these components are available only at increasing economic and environmental costs. As an important contribution to a sustainable future, chemistry and its products must be adapted to a circular economy (CE)—a system aimed at eliminating waste, circulating and recycling products, and saving resources and the environment.Nearly 140,000 industrial chemicals are marketed worldwide, and new chemicals are becoming more complex (e.g., stereochemistry, functional groups)

Pollution is the largest source of premature death in the developing world, causing approximately three times more deaths than HIV/AIDS, tuberculosis and malaria combined (2018 Report of the Lancet Commission on pollution and health). It disproportionately affects persons, groups and peoples in vulnerable situations reflecting both historical and ongoing discrimination, racism, and power imbalances that have given rise to powerful social movements for environmental justice. Those responsible for the harmful impacts of hazardous substances must be held legally accountable for

The aim of the guidance is to advance broader agreement on a general approach and criteria for the selection of safer alternatives, with a focus on chemical substitution. It is intended to advance a consistent understanding of the minimum requirements needed to determine whether a chemical alternative is safer than the priority chemical, product, or technology for substitution, independent of the entity performing the assessment or the alternatives assessment framework being used.The guidance focuses on minimum assessment criteria and recommended

Microplastic contamination of the marine environment is widespread, but the extent to which the marine food web is contaminated is not yet known. The aims of this study were to go beyond visual identification techniques and develop and apply a simple seafood sample cleanup, extraction, and quantitative analysis method using pyrolysis gas chromatography mass spectrometry to improve the detection of plastic contamination.This method allows the identification and quantification of polystyrene, polyethylene, polyvinyl chloride, polypropylene, and poly (methyl methacrylate) in the

We present a list of Chemicals of Concern (CoCs) in plastic toys. We started from available studies reporting chemical composition of toys to group plastic materials, as well as to gather mass fractions and function of chemicals in these materials. Chemical emissions from plastic toys and subsequent human exposures were then estimated using a series of models and a coupled near-field and far-field exposure assessment framework. Comparing human doses with reference doses shows high Hazard Quotients of up to 387

Global trade in illegal pesticides has been steadily growing in recent years, posing serious threats to agriculture, the environment, human health, and the economy. Evidence of this trend can be found in the increasing number of seizures of counterfeit, fake, and unauthorised pesticides, as well as their growing share in the global pesticide market. This paper identifies the main drivers and enablers of this illicit trade, and explores the potential of digital technologies, such as blockchain, to support policies to

Reducing chemical pressure on human and environmental health is an integral part of the global sustainability agenda. Guidelines for deriving globally applicable, life cycle–based indicators are required to consistently quantify toxicity impacts from chemical emissions as well as from chemicals in consumer products. In response, we elaborate the methodological framework and present recommendations for advancing near-field/far-field exposure and toxicity characterization, and for implementing these recommendations into the scientific consensus model USEtox.The present work was supported by the “Global Best Practices

The report examines the class approach for PFAS as it applies to the textile sector, which covers a wide variety of consumer products and connects two important issues covered in the SAICM context. The textile sector is an appropriate choice given the environmental significance of the sector and the scope of PFAS used within it. Both the quantity of PFAS in use and the variety of uses make this sector a priority for action. Furthermore, the nature of the sector—with